abstract：:Oxidative stress, resulting from excessive generation of reactive oxygen species (ROS), plays a pivotal role in the initiation and progression of inflammatory bowel disease (IBD). To develop an efficacious and safe nanotherapy against IBD, we designed and developed a superoxide dismutase/catalase mimetic nanomedicine ...

journal_title：Biomaterials

authors： Zhang Q,Tao H,Lin Y,Hu Y,An H,Zhang D,Feng S,Hu H,Wang R,Li X,Zhang J

更新日期：2016-10-01 00:00:00

abstract：:Nanotherapeutics have been investigated for years, but only modest survival benefits were observed clinic. This is partially attributed to the short and rapid elimination of nanodrug after intravenous administration. In this study, a long circulation single wall carbon nanotube (SWCNT) complex was successfully fabrica...

journal_title：Biomaterials

authors： Xie L,Wang G,Zhou H,Zhang F,Guo Z,Liu C,Zhang X,Zhu L

更新日期：2016-10-01 00:00:00

abstract：:To avoid the overheating effect of excitation light and improve the efficacy of photodynamic therapy (PDT) of upconversion nanoplatform, a novel nanoprobe based on 808 nm-excited upconversion nanocomposites (T-UCNPs@Ce6@mSiO2) with low heating effect and deep penetration has been successfully constructed for targeted ...

journal_title：Biomaterials

authors： Zeng L,Pan Y,Zou R,Zhang J,Tian Y,Teng Z,Wang S,Ren W,Xiao X,Zhang J,Zhang L,Li A,Lu G,Wu A

更新日期：2016-10-01 00:00:00

abstract：:Effective real-time and long-time in vivo imaging for flap perfusion requires bright and stable imaging agents whose emissions can effectively penetrate live tissues without photobleaching. Compared to the standard imaging agent today - intraoperative indocyanine green (ICG), quantum dots (QDs) is a more attractive al...

journal_title：Biomaterials

authors： Feng S,Chen J,Wo Y,Li Y,Chen S,Zhang Y,Zhang W

更新日期：2016-10-01 00:00:00

abstract：:Although dendritic nanoparticles have been prepared by many different methods, control over their degree of branching (DB) is still impossible, preventing us from understanding the effect of the DB on the properties of the nanodendrites as cancer therapeutics. Herein, we developed a novel seed-mediated method to prepa...

journal_title：Biomaterials

authors： Qiu P,Yang M,Qu X,Huai Y,Zhu Y,Mao C

更新日期：2016-10-01 00:00:00

abstract：:Three-dimensional constructs formed by cells embedded in an exogenous scaffold could not represent a faithful in vitro replica of native and functional tissues. In this work we produced an endogenous human skin equivalent by means of a tissue engineering process that induces the full morphogenesis of functional dermal...

journal_title：Biomaterials

authors： Casale C,Imparato G,Urciuolo F,Netti PA

更新日期：2016-09-01 00:00:00

abstract：:Parkinson's disease (PD) is one of the most common neurodegenerative diseases. Activins are members of the superfamily of transforming growth factors and have many potential neuroprotective effects. Herein, at the first place, we verified activin B's neuroprotective role in a PD model, and revealed that activin B's fa...

journal_title：Biomaterials

authors： Li J,Darabi M,Gu J,Shi J,Xue J,Huang L,Liu Y,Zhang L,Liu N,Zhong W,Zhang L,Xing M,Zhang L

更新日期：2016-09-01 00:00:00

abstract：:As peripheral arterial disease (PAD) results in muscle ischemia and neovascularization, it has been claimed that nanoparticles can passively accumulate in ischemic tissues through the enhanced permeability and retention (EPR) effect. At this time, a quantitative evaluation of the passive targeting capabilities of nano...

journal_title：Biomaterials

authors： England CG,Im HJ,Feng L,Chen F,Graves SA,Hernandez R,Orbay H,Xu C,Cho SY,Nickles RJ,Liu Z,Lee DS,Cai W

更新日期：2016-09-01 00:00:00

abstract：:The development of synthetic hydrogels analogs for the extracellular matrix has proven a useful and important tool to study the role of specific signals on biological outcomes in vitro and to serve as scaffolds for tissue repair. Although the importance of physical properties (e.g. microstructure and stiffness) in the...

journal_title：Biomaterials

authors： Darling NJ,Hung YS,Sharma S,Segura T

更新日期：2016-09-01 00:00:00

abstract：:Polyacrylamide hydrogels have been used extensively to study cell responses to the mechanical and biochemical properties of extracellular matrix substrates. A key step in fabricating these substrates is the conjugation of cell adhesion proteins to the polyacrylamide surfaces, which typically involves nonspecifically a...

journal_title：Biomaterials

authors： Lee JP,Kassianidou E,MacDonald JI,Francis MB,Kumar S

更新日期：2016-09-01 00:00:00

abstract：:Theranostic nanoagents which integrate diagnostic and therapeutic moieties into a single platform have attracted broad attention in cancer therapy, however the development of more effective and less toxic diagnostic and therapeutic interventions is still of great urgency. Herein, novel core-shell PB@MIL-100(Fe) dual m...

journal_title：Biomaterials

authors： Wang D,Zhou J,Chen R,Shi R,Zhao G,Xia G,Li R,Liu Z,Tian J,Wang H,Guo Z,Wang H,Chen Q

更新日期：2016-09-01 00:00:00

abstract：:Among the many applications for carbon nanotubes (CNTs), their use in medicine has drawn special attention due to their potential for a variety of therapeutic and diagnostic applications. As progress toward clinical applications continues, monitoring CNTs in vivo will be essential to evaluate their biodistribution, po...

journal_title：Biomaterials

authors： Hernández-Rivera M,Zaibaq NG,Wilson LJ

更新日期：2016-09-01 00:00:00

abstract：:Toll-like receptor 4 (TLR4) plays a critical role in the innate immune system. Stimulation of TLR4 occurs upon binding lipopolysaccharide (LPS), a component of Gram-negative bacterial cell walls. Due to the potency of the induced inflammatory response, there is a growing interest in agents that can most proximally mod...

journal_title：Biomaterials

authors： Foit L,Thaxton CS

更新日期：2016-09-01 00:00:00

abstract：:The design of peptide-based subunit vaccine formulations for the direct delivery of tumor antigen peptides (Aps) to dendritic cells (DCs) localized within draining lymph nodes (DLNs) is challenging. Mature DCs (mDCs) are abundantly distributed within DLNs but have dramatically reduced endocytic uptake and antigen-proc...

journal_title：Biomaterials

authors： Qian Y,Jin H,Qiao S,Dai Y,Huang C,Lu L,Luo Q,Zhang Z

更新日期：2016-08-01 00:00:00

abstract：:Tissue engineering strategies for repairing and regenerating articular cartilage face critical challenges to recapitulate the dynamic and complex biochemical microenvironment of native tissues. One approach to mimic the biochemical complexity of articular cartilage is through the use of recombinant bacterial collagens...

journal_title：Biomaterials

authors： Parmar PA,Skaalure SC,Chow LW,St-Pierre JP,Stoichevska V,Peng YY,Werkmeister JA,Ramshaw JA,Stevens MM

更新日期：2016-08-01 00:00:00

abstract：:Envelope, capsid and nucleic acids are key viral components that are all involved in crucial events during virus infection. Thus simultaneous labeling of these key components is an indispensable prerequisite for monitoring comprehensive virus infection process and dissecting virus infection mechanism. Baculovirus was ...

journal_title：Biomaterials

authors： Wen L,Lin Y,Zhang ZL,Lu W,Lv C,Chen ZL,Wang HZ,Pang DW

更新日期：2016-08-01 00:00:00

abstract：:Ultrasoft biomaterials-polymers, gels, and human soft tissues with an elastic modulus less than ∼100 kPa-are increasingly used in medical devices. While bacterial interactions (adhesion and biofilm formation) have been extensively studied on stiffer materials, little is known about how bacteria colonize ultrasoft mate...

journal_title：Biomaterials

authors： Wang Y,Guan A,Isayeva I,Vorvolakos K,Das S,Li Z,Phillips KS

更新日期：2016-07-01 00:00:00

abstract：:Anti-VEGF drugs that are used in conjunction with laser ablation to treat patients with diabetic retinopathy suffer from short half-lives in the vitreous of the eye resulting in the need for frequent intravitreal injections. To improve the intravitreal half-life of anti-VEGF drugs, such as the VEGF decoy receptor sFlt...

journal_title：Biomaterials

authors： Altiok EI,Santiago-Ortiz JL,Svedlund FL,Zbinden A,Jha AK,Bhatnagar D,Loskill P,Jackson WM,Schaffer DV,Healy KE

更新日期：2016-07-01 00:00:00

abstract：:Semiconductor quantum dots and upconversion nanoparticles have been broadly used for live cell imaging due to their color tunability and photostability etc. However, these inorganic materials often contain heavy metals and potentially have metabolism problems. To overcome these issues, herein, we report a type of orga...

journal_title：Biomaterials

authors： Xu R,Huang L,Wei W,Chen X,Zhang X,Zhang X

更新日期：2016-07-01 00:00:00

abstract：:Engineered stem cell (SC)-based therapy holds enormous promise for treating the incurable brain cancer glioblastoma (GBM). Retaining the cytotoxic SCs in the surgical cavity after GBM resection is one of the greatest challenges to this approach. Here, we describe a biocompatible electrospun nanofibrous scaffold (bENS)...

journal_title：Biomaterials

authors： Bagó JR,Pegna GJ,Okolie O,Mohiti-Asli M,Loboa EG,Hingtgen SD

更新日期：2016-06-01 00:00:00

abstract：:microRNA-124 (miR-124), the most abundant miRNA of the CNS, was recently shown to modulate the polarization of activated microglia and infiltrating macrophages towards the anti-inflammatory M2 phenotype and protect neurons in various ways after brain disease. In ischemic stroke, microglia and macrophages of a detrimen...

journal_title：Biomaterials

authors： Hamzei Taj S,Kho W,Riou A,Wiedermann D,Hoehn M

更新日期：2016-06-01 00:00:00

abstract：:Introducing drugs into gene delivery systems to fabricate co-delivery systems for synergy therapy has become a promising strategy for tumor therapy. In this study, a dual responsive co-delivery system RHD/p53 was fabricated to enhance the antitumor efficacy with a low dose of doxorubicin (DOX). The reducible branched ...

journal_title：Biomaterials

authors： Chen S,Lei Q,Li SY,Qin SY,Jia HZ,Cheng YJ,Zhang XZ

更新日期：2016-06-01 00:00:00

abstract：:A major hindrance in islet transplantation as a feasible therapeutic approach for patients with type 1 diabetes is the insufficient oxygenation of the grafts, which results in cell death in portions of the implant. Here we address this limitation through the application of oxygen-generating microparticles (MP) and a f...

journal_title：Biomaterials

authors： Montazeri L,Hojjati-Emami S,Bonakdar S,Tahamtani Y,Hajizadeh-Saffar E,Noori-Keshtkar M,Najar-Asl M,Ashtiani MK,Baharvand H

更新日期：2016-05-01 00:00:00

abstract：:Monocytes are actively recruited from the circulation into developing atherosclerotic plaques. In the plaque, monocytes differentiate into macrophages and eventually form foam cells. Continued accumulation of foam cells can lead to plaque rupture and subsequent myocardial infarction. X-ray computed tomography (CT) is ...

journal_title：Biomaterials

authors： Chhour P,Naha PC,O'Neill SM,Litt HI,Reilly MP,Ferrari VA,Cormode DP

更新日期：2016-05-01 00:00:00

abstract：:Developing repair strategies for osteochondral tissue presents complex challenges due to its interfacial nature and complex zonal structure, consisting of subchondral bone, intermediate calcified cartilage and the superficial cartilage regions. In this study, the long term ability of a multi-layered biomimetic collage...

journal_title：Biomaterials

authors： Levingstone TJ,Ramesh A,Brady RT,Brama PAJ,Kearney C,Gleeson JP,O'Brien FJ

更新日期：2016-05-01 00:00:00

abstract：:Poly(3, 4-ethylenedioxythiophene)-coated carbon microfibers (PEDOT-MFs) hold promise for developing advanced neuroprostheses and neural repair devices. We investigated the chronic cellular responses to PEDOT-MFs implanted into the uninjured and the transected rat spinal cord, and compared the effects of polymer surfac...

journal_title：Biomaterials

authors： Alves-Sampaio A,García-Rama C,Collazos-Castro JE

更新日期：2016-05-01 00:00:00

abstract：:The therapeutic efficacy of nanoscale anticancer drug delivery systems is severely truncated by their low tumor-targetability and inefficient drug release at the target site. Here, we report the design and development of novel endosomal pH-activatable paclitaxel prodrug micelles based on hyaluronic acid-b-dendritic ol...

journal_title：Biomaterials

authors： Zhong Y,Goltsche K,Cheng L,Xie F,Meng F,Deng C,Zhong Z,Haag R

更新日期：2016-04-01 00:00:00

abstract：:The immune system is a powerful resource for the eradication of cancer, but to overcome the low immunogenicity of tumor cells, a sufficiently strong CD8(+) T cell-mediated adaptive immune response is required. Nanoparticulate biomaterials represent a potentially effective delivery system for cancer vaccines, as they c...

journal_title：Biomaterials

authors： Molino NM,Neek M,Tucker JA,Nelson EL,Wang SW

更新日期：2016-04-01 00:00:00

abstract：:The development of an efficient colorectal cancer therapy is currently a public health priority. In the present work, we proposed a multifunctional theranostic micellar drug delivery system utilizing cationic PDMA-block-poly(ε-caprolactone) (PDMA-b-PCL) micelles as nanocarriers of SN-38 (7-ethyl-10-hydroxycamptothecin...

journal_title：Biomaterials

authors： Lee SY,Yang CY,Peng CL,Wei MF,Chen KC,Yao CJ,Shieh MJ

更新日期：2016-04-01 00:00:00

abstract：:The development of topical microbicides is a valid approach to protect the genital mucosa from sexually transmitted infections that cannot be contained with effective vaccination, like HSV and HIV infections. A suitable target of microbicides is the interaction between viral proteins and cell surface heparan sulfate p...

journal_title：Biomaterials

authors： Donalisio M,Quaranta P,Chiuppesi F,Pistello M,Cagno V,Cavalli R,Volante M,Bugatti A,Rusnati M,Ranucci E,Ferruti P,Lembo D

更新日期：2016-04-01 00:00:00

abstract：:H2O2-specific peroxalate chemiluminescence is recognized as a potential signal for sensitive in vivo imaging of inflammation but the effect of underlying peroxalate-emitter energetics on its efficiency has rarely been understood. Here we report a simple nanophotonic way of boosting near-infrared chemiluminescence with...

journal_title：Biomaterials

authors： Seo YH,Singh A,Cho HJ,Kim Y,Heo J,Lim CK,Park SY,Jang WD,Kim S

更新日期：2016-04-01 00:00:00

abstract：:ROCK activity increases due to ECM rigidity in the tumor microenvironment and promotes a malignant phenotype via actomyosin contractility. Invasive migration is facilitated by actin-rich adhesive protrusions known as invadopodia that degrade the ECM. Invadopodia activity is dependent on matrix rigidity and contractile...

journal_title：Biomaterials

authors： Jerrell RJ,Parekh A

更新日期：2016-04-01 00:00:00

abstract：:Implant-associated infections represent a significant health problem and financial burden on healthcare systems. Current strategies for the treatment or prevention of such infections are still inadequate and new strategies are needed in this era of antibiotic resistance. Melimine, a synthetic antimicrobial peptide wit...

journal_title：Biomaterials

authors： Chen R,Willcox MD,Ho KK,Smyth D,Kumar N

更新日期：2016-04-01 00:00:00

abstract：:This study suggests a novel method of stabilizing fragile porcine islets to prevent the dissociation after isolation and reducing immune cell invasion in a combination therapy of 'surface camouflaging' and immunosuppressive drugs (FK506, Rapamycin, MR-1, anti-CD19 mAb, and Clodrosome(®)) to effectively alleviate overa...

journal_title：Biomaterials

authors： Haque MR,Jeong JH,Byun Y

更新日期：2016-04-01 00:00:00

abstract：:Tumor-homing cytotoxic stem cell (SC) therapy is a promising new approach for treating the incurable brain cancer glioblastoma (GBM). However, problems of retaining cytotoxic SCs within the post-surgical GBM resection cavity are likely to significantly limit the clinical utility of this strategy. Here, we describe a n...

journal_title：Biomaterials

authors： Bagó JR,Pegna GJ,Okolie O,Hingtgen SD

更新日期：2016-04-01 00:00:00

abstract：:The clinical application of nanoparticular Gd(III) based contrast agents for tumor molecular MRI has been hindered by safety concerns associated with prolonged tissue retention, although they can produce strong tumor enhancement. In this study, a targeted well-defined cyclodextrin-based nanoglobular contrast agent was...

journal_title：Biomaterials

authors： Zhou Z,Han Z,Lu ZR

更新日期：2016-04-01 00:00:00

abstract：:The peripheral nerve contains three barriers which include the blood-nerve barrier consisting of endoneurial vessels and the perineurium as well as autotypic junctions in Schwann cells. The perineurium prevents diffusion of perineurally injected drugs that can be used for selective regional pain control. It is compose...

journal_title：Biomaterials

authors： Yang S,Krug SM,Heitmann J,Hu L,Reinhold AK,Sauer S,Bosten J,Sommer C,Fromm M,Brack A,Rittner HL

更新日期：2016-03-01 00:00:00

abstract：:Inherent neuronal and circulating progenitor cells play important roles in facilitating neuronal and functional recovery post stroke. However, this endogenous repair process is rather limited, primarily due to unfavorable conditions in the infarcted brain involving reactive oxygen species (ROS)-mediated oxidative stre...

journal_title：Biomaterials

authors： Petro M,Jaffer H,Yang J,Kabu S,Morris VB,Labhasetwar V

更新日期：2016-03-01 00:00:00

abstract：:In this study, we used deoxyribozyme (DNAzyme) functionalized gold nanoparticles (AuNPs) to catalytically silence tumor necrosis factor-α (TNF-α) in vivo as a potential therapeutic for myocardial infarction (MI). Using primary macrophages as a model, we demonstrated 50% knockdown of TNF-α, which was not attainable usi...

journal_title：Biomaterials

authors： Somasuntharam I,Yehl K,Carroll SL,Maxwell JT,Martinez MD,Che PL,Brown ME,Salaita K,Davis ME

更新日期：2016-03-01 00:00:00

abstract：UNLABELLED:Scarcity of donor tissue to treat corneal blindness and the need to deliver stem cells or pharmacologic agents to ensure corneal graft survival are major challenges. Here, new composite collagen-based hydrogels are developed as implants to restore corneal transparency while serving as a possible reservoir fo...

journal_title：Biomaterials

authors： Rafat M,Xeroudaki M,Koulikovska M,Sherrell P,Groth F,Fagerholm P,Lagali N

更新日期：2016-03-01 00:00:00